Dysbiosis modulates CD8+ tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection.

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Title: Dysbiosis modulates CD8+ tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection.
Authors: Jayaraman S; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Mahalingam S; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Lederman MM; Department of Medicine, Division of Infectious Diseases & HIV Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Cleveland, OH 44106, USA., Faddoul F; Advanced Education in General Dentistry, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Paes da Silva A; Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Asaad R; University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Cleveland, OH 44106, USA., Shriver LP; Department of Chemistry, Center for Metabolomics and Isotope Tracing, Washington University, Saint Louis, MO 63110, USA., Bhaskaran N; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Schneider E; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Heine G; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Taylor T; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Horne S; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Yoon A; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Zhu Z; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Zhang L; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Burgener A; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Lewin G; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Pandiyan P; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Center for AIDS Research, Case Western Reserve University, Cleveland, OH 44106, USA.
Source: IScience [iScience] 2025 Oct 03; Vol. 28 (11), pp. 113679. Date of Electronic Publication: 2025 Oct 03 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2025.113679