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Dysbiosis modulates CD8+ tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection.

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Title: Dysbiosis modulates CD8+ tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection.
Authors: Jayaraman S; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Mahalingam S; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Lederman MM; Department of Medicine, Division of Infectious Diseases & HIV Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Cleveland, OH 44106, USA., Faddoul F; Advanced Education in General Dentistry, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Paes da Silva A; Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Asaad R; University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Cleveland, OH 44106, USA., Shriver LP; Department of Chemistry, Center for Metabolomics and Isotope Tracing, Washington University, Saint Louis, MO 63110, USA., Bhaskaran N; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Schneider E; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Heine G; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Taylor T; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Horne S; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Yoon A; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Zhu Z; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Zhang L; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Burgener A; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Lewin G; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Pandiyan P; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Center for AIDS Research, Case Western Reserve University, Cleveland, OH 44106, USA.
Source: IScience [iScience] 2025 Oct 03; Vol. 28 (11), pp. 113679. Date of Electronic Publication: 2025 Oct 03 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: Dysbiosis modulates CD8<superscript>+</superscript> tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection.
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  Data: <searchLink fieldCode="AU" term="%22Jayaraman+S%22">Jayaraman S</searchLink>; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Mahalingam+S%22">Mahalingam S</searchLink>; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Lederman+MM%22">Lederman MM</searchLink>; Department of Medicine, Division of Infectious Diseases & HIV Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Faddoul+F%22">Faddoul F</searchLink>; Advanced Education in General Dentistry, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Paes+da+Silva+A%22">Paes da Silva A</searchLink>; Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Asaad+R%22">Asaad R</searchLink>; University Hospitals Cleveland Medical Center AIDS Clinical Trials Unit, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Shriver+LP%22">Shriver LP</searchLink>; Department of Chemistry, Center for Metabolomics and Isotope Tracing, Washington University, Saint Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Bhaskaran+N%22">Bhaskaran N</searchLink>; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+E%22">Schneider E</searchLink>; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Heine+G%22">Heine G</searchLink>; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+T%22">Taylor T</searchLink>; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Horne+S%22">Horne S</searchLink>; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Yoon+A%22">Yoon A</searchLink>; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Burgener+A%22">Burgener A</searchLink>; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Lewin+G%22">Lewin G</searchLink>; Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Pandiyan+P%22">Pandiyan P</searchLink>; Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Center for AIDS Research, Case Western Reserve University, Cleveland, OH 44106, USA.
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