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Inflammasome targeting for periodontitis prevention is sex dependent.

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Title: Inflammasome targeting for periodontitis prevention is sex dependent.
Authors: Alves T; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Swanson KV; Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC 27599.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599., Girnary MS; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Freire M; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA 92093.; Department of Genomic Medicine and Infectious Diseases, J. Craig Venter Institute, La Jolla, CA 92037., Moss K; Department of Biostatistics and Health Data Science, School of Medicine, University of Indiana, Indianapolis, IN 46202., Divaris K; Department of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Beck J; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Santos PCP; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Brickey WJ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599., Wrobel JA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599., Min HY; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Syed M; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Morelli T; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Seaman WT; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892., Preisser JS; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599., Hu D; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599., Preisser H; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Makhanova N; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Susin C; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Vias NP; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Styner M; Division of Endocrinology and Metabolism, School of Medicine, University of North Carolina, Chapel Hill, NC 27599., Zhang S; Periodontics Department, College of Dentistry, University of Iowa, Iowa City, IA 52242., Pirih FQ; Division of Regenerative and Reconstructive Sciences, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095., Chang J; Division of Regenerative and Reconstructive Sciences, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095., Gill HS; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695., Lietzan AD; Department of Biomedical Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599., Webster-Cyriaque J; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892., Ting JPY; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599., Marchesan JT; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 04; Vol. 122 (44), pp. e2507092122. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Alves+T%22">Alves T</searchLink>; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Swanson+KV%22">Swanson KV</searchLink>; Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC 27599.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Girnary+MS%22">Girnary MS</searchLink>; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Freire+M%22">Freire M</searchLink>; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA 92093.; Department of Genomic Medicine and Infectious Diseases, J. Craig Venter Institute, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Moss+K%22">Moss K</searchLink>; Department of Biostatistics and Health Data Science, School of Medicine, University of Indiana, Indianapolis, IN 46202.<br /><searchLink fieldCode="AU" term="%22Divaris+K%22">Divaris K</searchLink>; Department of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Beck+J%22">Beck J</searchLink>; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Santos+PCP%22">Santos PCP</searchLink>; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Brickey+WJ%22">Brickey WJ</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.; 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Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Vias+NP%22">Vias NP</searchLink>; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Styner+M%22">Styner M</searchLink>; Division of Endocrinology and Metabolism, School of Medicine, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Periodontics Department, College of Dentistry, University of Iowa, Iowa City, IA 52242.<br /><searchLink fieldCode="AU" term="%22Pirih+FQ%22">Pirih FQ</searchLink>; Division of Regenerative and Reconstructive Sciences, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095.<br /><searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; Division of Regenerative and Reconstructive Sciences, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095.<br /><searchLink fieldCode="AU" term="%22Gill+HS%22">Gill HS</searchLink>; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695.<br /><searchLink fieldCode="AU" term="%22Lietzan+AD%22">Lietzan AD</searchLink>; Department of Biomedical Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Webster-Cyriaque+J%22">Webster-Cyriaque J</searchLink>; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.<br /><searchLink fieldCode="AU" term="%22Ting+JPY%22">Ting JPY</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599.<br /><searchLink fieldCode="AU" term="%22Marchesan+JT%22">Marchesan JT</searchLink>; Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC 27599.
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