Differential prognostic impact of myelodysplasia-related gene mutations in a European cohort of 4978 intensively treated AML patients.

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Title: Differential prognostic impact of myelodysplasia-related gene mutations in a European cohort of 4978 intensively treated AML patients.
Authors: Bill M; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany.; Mildred Scheel Early Career Center, Medical Clinic and Policlinic I, University Hospital of the Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), Medical Faculty and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Eckardt JN; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany., Döhner K; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany., Röhnert MA; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany., Rausch C; Laboratory for Leukemia Diagnostics, Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Metzeler KH; Department of Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Spiekermann K; Laboratory for Leukemia Diagnostics, Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Stasik S; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany., Wurm AA; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany.; Mildred Scheel Early Career Center, Medical Clinic and Policlinic I, University Hospital of the Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), Medical Faculty and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Sauer T; German Cancer Research Center (DKFZ) and Medical Clinic V, University Hospital Heidelberg, Heidelberg, Germany., Scholl S; Klinik für Innere Medizin II, Jena University Hospital, Jena, Germany., Schnetzke U; Klinik für Innere Medizin II, Jena University Hospital, Jena, Germany., Hochhaus A; Klinik für Innere Medizin II, Jena University Hospital, Jena, Germany., Crysandt M; Department of Hematology, Oncology, Hemostaseology, and Cell Therapy, University Hospital RWTH Aachen, Aachen, Germany., Brümmendorf TH; Department of Hematology, Oncology, Hemostaseology, and Cell Therapy, University Hospital RWTH Aachen, Aachen, Germany., Krug U; DKMS Collection Center, Cologne, Germany., Wörmann B; Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Einsele H; Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany., Hiddemann W; Laboratory for Leukemia Diagnostics, Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Görlich D; Institute for Biostatistics and Clinical Research, University Muenster, Münster, Germany., Sauerland C; Institute for Biostatistics and Clinical Research, University Muenster, Münster, Germany., Steffen B; Medical Clinic II, University Hospital Frankfurt, Frankfurt (Main), Germany., Neubauer A; Department of Hematology, Oncology and Immunology, Philipps-University-Marburg, Marburg, Germany., Burchert A; Department of Hematology, Oncology and Immunology, Philipps-University-Marburg, Marburg, Germany., Schäfer-Eckart K; Department of Internal Medicine V, Paracelsus Medizinische Privatuniversität and University Hospital Nuremberg, Nuremberg, Germany., Berdel WE; Department of Medicine A, University Hospital Münster, Münster, Germany., Schliemann C; Department of Medicine A, University Hospital Münster, Münster, Germany., Krause SW; Department of Medicine 5, Uniklinikum Erlangen, Erlangen, Germany., Hänel M; Department of Internal Medicine III, Klinikum Chemnitz gGmbH, Chemnitz, Germany., Hanoun M; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany., Kaufmann M; Department of Hematology, Oncology and Palliative Care, Robert-Bosch-Hospital, Stuttgart, Germany., Fransecky L; Department of Internal Medicine, University Hospital Kiel, Kiel, Germany., Braess J; Hospital Barmherzige Brueder Regensburg, Regensburg, Germany., Schetelig J; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany., Middeke JM; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany., Bullinger L; Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Heuser M; Department of Internal Medicine IV, Hematology, Oncology, University Hospital Halle/Saale, Halle, Germany.; Department of Hematology, Hemostasis, Oncology & Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Thol F; Department of Hematology, Hemostasis, Oncology & Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Serve H; Medical Clinic II, University Hospital Frankfurt, Frankfurt (Main), Germany., Baldus CD; Department of Internal Medicine, University Hospital Kiel, Kiel, Germany., Platzbecker U; Department of Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Müller-Tidow C; German Cancer Research Center (DKFZ) and Medical Clinic V, University Hospital Heidelberg, Heidelberg, Germany., Válka J; Institute of Hematology and Blood Transfusion, Prague, Czech Republic., Šrámek J; Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czech Republic.; Histology and Embryology Department, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic., Weinbergerova B; Department of Internal Medicine, Hematology and Oncology, Masaryk University Hospital, Brno, Czech Republic., Mayer J; Department of Internal Medicine, Hematology and Oncology, Masaryk University Hospital, Brno, Czech Republic., Dumas PY; CHU Bordeaux, Service d'Hématologie Clinique et de Thérapie Cellulaire, Bordeaux, France., Bertoli S; Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Université de Toulouse, Toulouse, France., Delabesse E; Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Université de Toulouse, Toulouse, France., Récher C; Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Université de Toulouse, Toulouse, France., Pigneux A; CHU Bordeaux, Service d'Hématologie Clinique et de Thérapie Cellulaire, Bordeaux, France., Herold T; Laboratory for Leukemia Diagnostics, Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Hematology and Oncology, Munich Hospital Bogenhausen, Munich Municipal Hospital Group, Munich, Germany., Ganser A; Department of Hematology, Hemostasis, Oncology & Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Döhner H; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany., Bornhäuser M; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany.; Mildred Scheel Early Career Center, Medical Clinic and Policlinic I, University Hospital of the Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), Medical Faculty and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Thiede C; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany., Röllig C; Department of Internal Medicine I, University Hospital TU Dresden; Fetscherstraße 74; 01307 Dresden, Saxony, Germany. christoph.roellig@ukdd.de.
Source: Leukemia [Leukemia] 2026 Jan; Vol. 40 (1), pp. 63-71. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-025-02781-6