Cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma.

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Title: Cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma.
Authors: Chalabi Hajkarim M; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., May M; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Amin AD; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Jamison J; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Tagore S; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., D'Souza E; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Caprio L; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Walsh ZH; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Fan JL; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA., Zhang M; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA., Shah P; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Abuzaid S; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Michel A; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Dajiang S; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Wong W; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shaikh N; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Ramaradj P; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Bakir B; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Kluger MD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Surgery, Division of GI & Endocrine Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Chabot J; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Surgery, Division of GI & Endocrine Surgery, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Azizi E; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA.; Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA., Hibshoosh H; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Rustgi AK; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Division of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Raufi AG; Lifespan Cancer Institute, Rhode Island Hospital, Providence, RI, USA., Manji GA; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA. gam2140@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. gam2140@cumc.columbia.edu.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. gam2140@cumc.columbia.edu., Izar B; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. bi2175@cumc.columbia.edu.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.
Source: Nature genetics [Nat Genet] 2025 Nov; Vol. 57 (11), pp. 2728-2742. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-025-02345-5