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TET knockout cells transit between pluripotent states and exhibit precocious germline entry.

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Title: TET knockout cells transit between pluripotent states and exhibit precocious germline entry.
Authors: Pantier R; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR7104, INSERM U1258, Université de Strasbourg, 1 rue Laurent Fries, Illkirch, Cedex, France., Barbieri E; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland., Gonzalez Brito S; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland., Thomson E; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland., Tatar T; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland., Colby D; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland., Zhang M; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland.; Guangzhou National Laboratory, No. 9 XingDaoHuanBei Road, 510005, Guangzhou, China., Chambers I; Centre for Regenerative Medicine, Institute for Regeneration and Repair, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland. ichambers@ed.ac.uk.; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, Scotland. ichambers@ed.ac.uk.
Source: The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (23), pp. 7060-7089. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00597-9