The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.

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Title: The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.
Authors: Jana U; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Rodriguez OL; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lees W; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Engelbrecht E; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Vanwinkle Z; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Peres A; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Gibson WS; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA; Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Shields K; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Schultze S; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Dorgham A; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA., Emery M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Deikus G; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Eichler EE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Yaari G; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Smith ML; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA. Electronic address: ml.smith@louisville.edu., Watson CT; Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA. Electronic address: corey.watson@louisville.edu.
Source: Cell genomics [Cell Genom] 2026 Jan 14; Vol. 6 (1), pp. 101058. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-979X
DOI:10.1016/j.xgen.2025.101058