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A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1.

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Title: A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1.
Authors: Lamerton RE; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK., Martin EM; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK., Perry J; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA., Cunningham AF; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK., Watson SP; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK., Frelinger AL 3rd; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.
Source: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2025 Sep 24; Vol. 9 (7), pp. 103196. Date of Electronic Publication: 2025 Sep 24 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101703775 Publication Model: eCollection Cited Medium: Internet ISSN: 2475-0379 (Electronic) Linking ISSN: 24750379 NLM ISO Abbreviation: Res Pract Thromb Haemost Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2475-0379
DOI:10.1016/j.rpth.2025.103196