A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1.

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Title: A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1.
Authors: Lamerton RE; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK., Martin EM; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK., Perry J; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA., Cunningham AF; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK., Watson SP; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK., Frelinger AL 3rd; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.
Source: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2025 Sep 24; Vol. 9 (7), pp. 103196. Date of Electronic Publication: 2025 Sep 24 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101703775 Publication Model: eCollection Cited Medium: Internet ISSN: 2475-0379 (Electronic) Linking ISSN: 24750379 NLM ISO Abbreviation: Res Pract Thromb Haemost Subsets: PubMed not MEDLINE
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  Data: A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1.
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  Data: <searchLink fieldCode="AU" term="%22Lamerton+RE%22">Lamerton RE</searchLink>; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Martin+EM%22">Martin EM</searchLink>; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Perry+J%22">Perry J</searchLink>; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cunningham+AF%22">Cunningham AF</searchLink>; Department of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Watson+SP%22">Watson SP</searchLink>; Department of Cardiovascular Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Frelinger+AL+3rd%22">Frelinger AL 3rd</searchLink>; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%22101703775%22">Research and practice in thrombosis and haemostasis</searchLink> [Res Pract Thromb Haemost] 2025 Sep 24; Vol. 9 (7), pp. 103196. <i>Date of Electronic Publication: </i>2025 Sep 24 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101703775 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2475-0379 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224750379%22">24750379 </searchLink><i>NLM ISO Abbreviation: </i>Res Pract Thromb Haemost <i>Subsets: </i>PubMed not MEDLINE
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