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A novel TIRAP-MyD88 inhibitor blocks TLR7- and TLR8-induced type I IFN responses.

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Title: A novel TIRAP-MyD88 inhibitor blocks TLR7- and TLR8-induced type I IFN responses.
Authors: Nilsen KE; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Stenvik J; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Skjesol A; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Mestvedt IB; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Bakke SS; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Giambelluca MS; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Gravastrand CS; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Elamurugan K; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Ryan L; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Espevik T; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Infectious Diseases, Clinic of Medicine, St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway., Yurchenko M; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Infectious Diseases, Clinic of Medicine, St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway.
Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Dec 01; Vol. 214 (12), pp. 3514-3528.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel TIRAP-MyD88 inhibitor blocks TLR7- and TLR8-induced type I IFN responses.
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  Data: <searchLink fieldCode="AU" term="%22Nilsen+KE%22">Nilsen KE</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Stenvik+J%22">Stenvik J</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Skjesol+A%22">Skjesol A</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Mestvedt+IB%22">Mestvedt IB</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Bakke+SS%22">Bakke SS</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Giambelluca+MS%22">Giambelluca MS</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Gravastrand+CS%22">Gravastrand CS</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Elamurugan+K%22">Elamurugan K</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Ryan+L%22">Ryan L</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Espevik+T%22">Espevik T</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Infectious Diseases, Clinic of Medicine, St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Yurchenko+M%22">Yurchenko M</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Infectious Diseases, Clinic of Medicine, St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway.
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  Data: <searchLink fieldCode="JN" term="%222985117R%22">Journal of immunology (Baltimore, Md. : 1950)</searchLink> [J Immunol] 2025 Dec 01; Vol. 214 (12), pp. 3514-3528.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985117R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-6606 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221767%22">00221767 </searchLink><i>NLM ISO Abbreviation: </i>J Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/jimmun/vkaf258
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        Text: English
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              M: 12
              Text: 2025 Dec 01
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              Y: 2025
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