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Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.

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Title: Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.
Authors: Fonseca MM; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Gelblung O; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Pennypacker SD; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Brooks T; Section on Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Cancer Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Limia M; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Morgan JW; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Zhu X; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Tovias-Sanchez LC; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Pluma-Pluma A; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Martinez RE; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Eber MR; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Park SH; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Furdui CM; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Awasthi D; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Emmanuelli A; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Cho BA; Precision Immunology Institute, Hess Center for Science and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Tan C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Shalowitz DI; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; West Michigan Cancer Center, Kalamazoo, MI 49007, USA., Lentz SS; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Kelly M; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., O'Brien Cox A; Proteomics and Metabolomics Shared Resource, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Macnamara L; Proteomics and Metabolomics Shared Resource, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Hsu FC; Division of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Shiozawa Y; Department of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA., Hsu W; Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Iwawaki T; Division of Cell Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan., Miller LD; Department of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA., Lesser GJ; Department of Cancer Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Strowd R; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Romero-Sandoval EA; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Oct 29; Vol. 17 (822), pp. eady5288. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.
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  Data: <searchLink fieldCode="AU" term="%22Fonseca+MM%22">Fonseca MM</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Gelblung+O%22">Gelblung O</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Pennypacker+SD%22">Pennypacker SD</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Brooks+T%22">Brooks T</searchLink>; Section on Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Cancer Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Limia+M%22">Limia M</searchLink>; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+JW%22">Morgan JW</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Tovias-Sanchez+LC%22">Tovias-Sanchez LC</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Pluma-Pluma+A%22">Pluma-Pluma A</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+RE%22">Martinez RE</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Eber+MR%22">Eber MR</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Furdui+CM%22">Furdui CM</searchLink>; Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Awasthi+D%22">Awasthi D</searchLink>; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Emmanuelli+A%22">Emmanuelli A</searchLink>; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Cho+BA%22">Cho BA</searchLink>; Precision Immunology Institute, Hess Center for Science and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Tan+C%22">Tan C</searchLink>; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Shalowitz+DI%22">Shalowitz DI</searchLink>; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; West Michigan Cancer Center, Kalamazoo, MI 49007, USA.<br /><searchLink fieldCode="AU" term="%22Lentz+SS%22">Lentz SS</searchLink>; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+M%22">Kelly M</searchLink>; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+Cox+A%22">O'Brien Cox A</searchLink>; Proteomics and Metabolomics Shared Resource, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Macnamara+L%22">Macnamara L</searchLink>; Proteomics and Metabolomics Shared Resource, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+FC%22">Hsu FC</searchLink>; Division of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Shiozawa+Y%22">Shiozawa Y</searchLink>; Department of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+W%22">Hsu W</searchLink>; Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Iwawaki+T%22">Iwawaki T</searchLink>; Division of Cell Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Miller+LD%22">Miller LD</searchLink>; Department of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Lesser+GJ%22">Lesser GJ</searchLink>; Department of Cancer Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Strowd+R%22">Strowd R</searchLink>; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.<br /><searchLink fieldCode="AU" term="%22Cubillos-Ruiz+JR%22">Cubillos-Ruiz JR</searchLink>; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Romero-Sandoval+EA%22">Romero-Sandoval EA</searchLink>; Pain Mechanisms Laboratory, Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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