GZMK+CD8+ T cells target a specific acinar cell type in Sjögren's disease.

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Title: GZMK+CD8+ T cells target a specific acinar cell type in Sjögren's disease.
Authors: Pranzatelli TJF; Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Department of Biology, University of Maryland, College Park, Maryland, USA., Perez P; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Ku A; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Matuck B; Lab of Oral & Craniofacial Innovation, Department of Innovation & Technology Research, ADA Science & Research Institute, Gaithersburg, Maryland, USA., Huynh K; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA., Sakai S; T-lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Abed M; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Jang SI; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Yamada E; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Dominick K; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Ahmed Z; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Oliver AJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Bogle R; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA., Easter QT; Lab of Oral & Craniofacial Innovation, Department of Innovation & Technology Research, ADA Science & Research Institute, Gaithersburg, Maryland, USA., Baer AN; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Pelayo E; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Khavandgar Z; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Kleiner DE; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Magone MT; Consult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA., Gupta S; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Lupus Clinical Trials Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA., Lessard C; Genes & Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Farris AD; Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Burbelo PD; Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Martin D; Genomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA., Morell RJ; Genomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA., Zheng C; Genomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA., Rachmaninoff N; Department of Biology, University of Maryland, College Park, Maryland, USA., Maldonado-Ortiz J; Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Tyc KM; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA., Qu X; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA., Aure M; Matrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Dezfulian MH; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA., Lake R; Laboratory of Genitourinary Cancer Pathogenesis (LCGP) Microscopy Core Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Teichmann SA; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Ensocell Therapeutics, BioData Innovation Centre, Wellcome Genome Campus, Cambridge, UK; Theory of Condensed Matter, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; CIFAR Macmillan Multi-scale Human Program, CIFAR, Toronto, Ontario, Canada., Barber DL; T-lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Tsoi LC; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA., Sowalsky AG; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Liu J; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA., Gudjonsson J; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA., Byrd KM; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Lab of Oral & Craniofacial Innovation, Department of Innovation & Technology Research, ADA Science & Research Institute, Gaithersburg, Maryland, USA; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, USA; VCU Massey Comprehensive Cancer Center, Bioinformatics Shared Resource Core, Virginia Commonwealth University, Richmond, Virginia, USA., Johnson PLF; Department of Biology, University of Maryland, College Park, Maryland, USA., Chiorini JA; Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Warner BM; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: blake.warner@nih.gov.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2026 May; Vol. 85 (5), pp. 880-898. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-2060
DOI:10.1016/j.ard.2025.08.014