Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effects in DIPG cells.
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| Title: | Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effects in DIPG cells. |
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| Authors: | Shen H; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia., Huynh QS; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Mudassar F; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Chang C; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Gloss B; Westmead Research Hub Core Facilities, Westmead Institute for Medical Research, Westmead, NSW, Australia., Ing P; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Ma S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, The Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, China., Gee H; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.; Western Sydney Radiation Oncology Network, Sydney, NSW, Australia., Hau E; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia. Eric.Hau@health.nsw.gov.au.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. Eric.Hau@health.nsw.gov.au.; Western Sydney Radiation Oncology Network, Sydney, NSW, Australia. Eric.Hau@health.nsw.gov.au., Cook KM; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia. kristina.cook@sydney.edu.au.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. kristina.cook@sydney.edu.au.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. kristina.cook@sydney.edu.au. |
| Source: | Cancer & metabolism [Cancer Metab] 2025 Oct 29; Vol. 13 (1), pp. 43. Date of Electronic Publication: 2025 Oct 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101607582 Publication Model: Electronic Cited Medium: Print ISSN: 2049-3002 (Print) Linking ISSN: 20493002 NLM ISO Abbreviation: Cancer Metab Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2049-3002 |
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| DOI: | 10.1186/s40170-025-00411-4 |
