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Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effects in DIPG cells.

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Title: Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effects in DIPG cells.
Authors: Shen H; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia., Huynh QS; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Mudassar F; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Chang C; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Gloss B; Westmead Research Hub Core Facilities, Westmead Institute for Medical Research, Westmead, NSW, Australia., Ing P; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia., Ma S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, The Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, China., Gee H; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.; Western Sydney Radiation Oncology Network, Sydney, NSW, Australia., Hau E; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia. Eric.Hau@health.nsw.gov.au.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. Eric.Hau@health.nsw.gov.au.; Western Sydney Radiation Oncology Network, Sydney, NSW, Australia. Eric.Hau@health.nsw.gov.au., Cook KM; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia. kristina.cook@sydney.edu.au.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. kristina.cook@sydney.edu.au.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. kristina.cook@sydney.edu.au.
Source: Cancer & metabolism [Cancer Metab] 2025 Oct 29; Vol. 13 (1), pp. 43. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607582 Publication Model: Electronic Cited Medium: Print ISSN: 2049-3002 (Print) Linking ISSN: 20493002 NLM ISO Abbreviation: Cancer Metab Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Huynh+QS%22">Huynh QS</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.<br /><searchLink fieldCode="AU" term="%22Mudassar+F%22">Mudassar F</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.<br /><searchLink fieldCode="AU" term="%22Chang+C%22">Chang C</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.<br /><searchLink fieldCode="AU" term="%22Gloss+B%22">Gloss B</searchLink>; Westmead Research Hub Core Facilities, Westmead Institute for Medical Research, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ing+P%22">Ing P</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.<br /><searchLink fieldCode="AU" term="%22Ma+S%22">Ma S</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, The Ministry of Education, College of Pharmacy, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Gee+H%22">Gee H</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.; Western Sydney Radiation Oncology Network, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hau+E%22">Hau E</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia. Eric.Hau@health.nsw.gov.au.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. Eric.Hau@health.nsw.gov.au.; Western Sydney Radiation Oncology Network, Sydney, NSW, Australia. Eric.Hau@health.nsw.gov.au.<br /><searchLink fieldCode="AU" term="%22Cook+KM%22">Cook KM</searchLink>; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, Westmead Institute for Medical Research, NSW, Westmead, Australia. kristina.cook@sydney.edu.au.; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. kristina.cook@sydney.edu.au.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. kristina.cook@sydney.edu.au.
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              Text: 2025 Oct 29
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