Optimization of Preclinical Rodent Research Models of Human Shock: Part One Intra-Abdominal Sepsis.

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Title: Optimization of Preclinical Rodent Research Models of Human Shock: Part One Intra-Abdominal Sepsis.
Authors: Rodhouse C; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Michael Z; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Byskosh A; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Boeno FP; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida., Hernandez-Rios M; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Park G; The Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, Florida State University College of Health and Human Sciences, Tallahassee, Florida., Dumitrescu S; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria., Fisler GM; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health and the Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.; Sepsis Laboratory, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Taylor MD; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health and the Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.; Sepsis Laboratory, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Abraham MN; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health and the Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.; Sepsis Laboratory, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Vo Q; Department of Neuroscience, Center for Translational Research on Neurodegenerative Diseases, McKnight Brain Institute, University of Florida, Gainesville, Florida., Charles A; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Lederer J; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Laitano O; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida., Rincon J; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida., Nagpal R; The Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, Florida State University College of Health and Human Sciences, Tallahassee, Florida., Chakrabarty P; Department of Neuroscience, Center for Translational Research on Neurodegenerative Diseases, McKnight Brain Institute, University of Florida, Gainesville, Florida., Casadesus G; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida., Osuchowski MF; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria., Deutschman CS; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health and the Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.; Sepsis Laboratory, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Elmezzi Graduate School of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Mohr A; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Maile R; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Scott M; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania., Efron P; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Bible L; Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.
Source: Shock (Augusta, Ga.) [Shock] 2026 Apr 01; Vol. 65 (4), pp. 571-587. Date of Electronic Publication: 2025 Nov 04.
Publication Type: Journal Article; Review
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-0514 (Electronic) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1540-0514
DOI:10.1097/SHK.0000000000002742