Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy.

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Bibliographic Details
Title: Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy.
Authors: Sheng T; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Sundar R; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Medicine (Medical Oncology), Yale University, New Haven, Connecticut, USA., Srivastava S; Department of Medicine, National University Hospital, Singapore., Ong X; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Tay ST; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Ma H; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Uchihara T; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Lian BSX; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Hagihara T; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Kong MS; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Xu C; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Ho SWT; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Huang KK; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Tan ALK; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Ng MSW; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Toh J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Ng CSY; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore., Nasca V; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Pircher CC; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Randon G; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Giordano S; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Corso S; Department of Oncology, University of Torino, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Lum JHY; Department of Pathology, National University Hospital, Singapore., Teh M; Department of Pathology, National University Hospital, Singapore., Zhao JJ; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; Department of Medicine, National University Hospital, Singapore., So JBY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Surgery, National University of Singapore, Singapore.; Department of Surgery, University Surgical Cluster, National University Health System, Singapore.; NUS Centre for Cancer Research, National University of Singapore, Singapore., Sabella G; Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Prabhakar S; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Lee J; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea., Yong WP; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Ng MCH; Division of Medical Oncology, National Cancer Centre, Singapore., Shitara K; Department of Gastrointestinal Surgery, National Cancer Center Hospital East, Kashiwa, Japan., Gasparello J; Department of Medicine, University of Padua, Padua, Italy., Fassan M; Department of Medicine, University of Padua, Padua, Italy.; Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy., Pietrantonio F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy filippo.pietrantonio@istitutotumori.mi.it gmstanp@duke-nus.edu.sg., Tan P; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore filippo.pietrantonio@istitutotumori.mi.it gmstanp@duke-nus.edu.sg.; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singhealth/Duke-NUS Institute of Precision Medicine, National Heart Centre, Singapore.
Source: Gut [Gut] 2026 Mar 06; Vol. 75 (4), pp. 733-747. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-3288
DOI:10.1136/gutjnl-2024-334667