Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity.

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Title: Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity.
Authors: Yu C; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA; RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA., Wang C; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA; RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA. Electronic address: chen.wang10@umassmed.edu., Forman T; School of Biological Sciences, University of California, San Diego, San Diego, CA 92093, USA., Xie J; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA; RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA., Major S; School of Biological Sciences, University of California, San Diego, San Diego, CA 92093, USA., Fang MX; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA; Brown University, Providence, RI 02912, USA., Voyer JE; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA; RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA., Pogliano J; School of Biological Sciences, University of California, San Diego, San Diego, CA 92093, USA., Fu TM; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA; RNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA 01655, USA. Electronic address: tianmin.fu@umassmed.edu.
Source: Molecular cell [Mol Cell] 2025 Nov 20; Vol. 85 (22), pp. 4243-4253.e4. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4164
DOI:10.1016/j.molcel.2025.10.007