Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial.

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Title: Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial.
Authors: Hirschfield GM; The Autoimmune and Rare Liver Disease Programme, Division of Gastroenterology and Hepatology, University Health Network, Toronto General Hospital, Toronto, ON, Canada. Electronic address: gideon.hirschfield@uhn.ca., Bowlus CL; Division of Gastroenterology and Hepatology, University of California Davis School of Medicine, Sacramento, CA, USA., Jones DEJ; Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK., Kremer AE; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Mayo MJ; University of Texas Southwestern Medical School, Dallas, TX, USA., Tanaka A; Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan., Andreone P; Medicina Interna Metabolica, Baggiovara Hospital, Azienda Ospedaliero-Universitaria di Modena and Università di Modena e Reggio Emilia, Modena, Italy., Jia J; Liver Research Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China., Jin Q; Department of Hepatology, The First Hospital of Jilin University, Changchun, China., Macías-Rodríguez RU; Division of Hepatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Cobitz AR; GSK, Collegeville, PA, USA., Currie BM; GSK, Collegeville, PA, USA., Gorey C; GSK, London, UK., Lazic I; GSK, London, UK., Podmore D; GSK, London, UK., Ribeiro A; GSK, Madrid, Spain., Shannon JB; GSK, Durham, NC, USA., Swift B; GSK, Durham, NC, USA., McLaughlin MM; GSK, Collegeville, PA, USA., Levy C; Division of Digestive Health and Liver Diseases and Schiff Center for Liver Diseases, University of Miami, Miami, FL, USA.
Corporate Authors: GLISTEN Study Group
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Jan; Vol. 11 (1), pp. 22-33. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2468-1253
DOI:10.1016/S2468-1253(25)00192-X