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Developmental PBDE exposure persistently impairs mast cell function in vivo and drives sex-specific morphological and transcriptional changes in bone marrow-derived mast cells.

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Title: Developmental PBDE exposure persistently impairs mast cell function in vivo and drives sex-specific morphological and transcriptional changes in bone marrow-derived mast cells.
Authors: Franges J; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., Malinowski L; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., De Alwis C; Department of Chemistry, North Carolina State University, Raleigh, NC, 27606, United States., Doolittle T; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., Li Y; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., Dixon H; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., Tang Y; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., Watson H; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., Peace J; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States., Jima D; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, United States; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27606, United States., Sombers L; Department of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, 32610 United States., McCarty G; Department of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, 32610 United States., Patisaul H; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, United States., Stapleton HM; Nicholas School of the Environment, Duke University, Durham, NC, 27710, United States., Duque-Wilckens N; Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27606, United States; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, United States. Electronic address: nduquew@ncsu.edu.
Source: Environmental research [Environ Res] 2026 Jan 01; Vol. 288 (Pt 1), pp. 123250. Date of Electronic Publication: 2025 Oct 31.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-0953
DOI:10.1016/j.envres.2025.123250