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Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome.

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Title: Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome.
Authors: Narendra VK; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Das T; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wierciszewski LJ; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Londoner RJ; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Biochemistry, Structural Biology, Cell Biology, Developmental Biology and Molecular Biology (BCMB) Allied Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA., Morrison JK; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA., Martindale P; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Devine T; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chen K; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Trombetta M; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kanno Y; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Casiano AE; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lareau CA; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lowe SW; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Gitlin AD; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. gitlina@mskcc.org.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA. gitlina@mskcc.org.; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. gitlina@mskcc.org.
Source: Nature [Nature] 2026 Jan; Vol. 649 (8099), pp. 1273-1281. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Narendra+VK%22">Narendra VK</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Das+T%22">Das T</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wierciszewski+LJ%22">Wierciszewski LJ</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Londoner+RJ%22">Londoner RJ</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Biochemistry, Structural Biology, Cell Biology, Developmental Biology and Molecular Biology (BCMB) Allied Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Morrison+JK%22">Morrison JK</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Martindale+P%22">Martindale P</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Devine+T%22">Devine T</searchLink>; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Trombetta+M%22">Trombetta M</searchLink>; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kanno+Y%22">Kanno Y</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Casiano+AE%22">Casiano AE</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lareau+CA%22">Lareau CA</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gitlin+AD%22">Gitlin AD</searchLink>; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. gitlina@mskcc.org.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA. gitlina@mskcc.org.; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. gitlina@mskcc.org.
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