Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var.
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| Title: | Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var. |
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| Authors: | Sung Y; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Yu YC; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Lee M; Research Institute, National Cancer Center, Goyang, 10408, Republic of Korea., Lim S; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Lee Y; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Kang M; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Kwon D; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Parajulee A; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Choi J; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Min DS; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Kim K; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Namkung W; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Kim YH; Research Institute, National Cancer Center, Goyang, 10408, Republic of Korea., Woo SM; Research Institute, National Cancer Center, Goyang, 10408, Republic of Korea.; Center for Liver and Pancreatobiliary Cancer, Hospital, National Cancer Center, Goyang, 10408, Republic of Korea., Kim ND; CoBX Bio Inc., 21 Yangji-ro, Gwangmyeong-si, Gyeonggi-do, 14345, Republic of Korea., Yoo HC; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea., Han JM; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea. jhan74@yonsei.ac.kr.; POSTECH Biotech Center, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea. jhan74@yonsei.ac.kr. |
| Source: | Nature communications [Nat Commun] 2025 Nov 03; Vol. 16 (1), pp. 9690. Date of Electronic Publication: 2025 Nov 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64730-2 |
