Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group.

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Title: Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group.
Authors: Serrarens C; Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.; Changes GGZ, Breda, the Netherlands., Toenders YJ; Orygen, Parkville, VIC, Australia.; Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.; Leiden University, Developmental and Educational Psychology, Leiden, the Netherlands.; Erasmus University Rotterdam, Erasmus School of Social and Behavioural Sciences, Rotterdam, the Netherlands., Pozzi E; Orygen, Parkville, VIC, Australia.; Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia., Aleman A; University of Groningen, Cognitive Neuroscience Center, Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, Groningen, the Netherlands., Alexander N; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Başgöze Z; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA., Belov V; Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), University Medical Center Göttingen (UMG), Göttingen, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany., Brosch K; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany.; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, USA., Bülow R; Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.; German Center for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany., Busatto GF; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brasil., Capitão LP; Psychological Neuroscience Laboratory, Psychology Research Centre (CIPsi), School of Psychology, University of Minho, Braga, Portugal., Connolly CG; Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA., Couvy-Duchesne B; University of Queensland, Institute for Molecular Bioscience, St. Lucia, QLD, Australia.; Sorbonne University, Paris Brain Institute (ICM), CNRS, INRIA, INSERM, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France., Cullen KR; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Bielefeld University, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Department of Psychiatry, Bielefeld, Germany., Davey CG; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia., de Zubicaray GI; School of Psychology and Counseling, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia., Dima D; Department of Psychology, School of Health and Psychological Sciences, City, University of London, London, UK.; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Dohm K; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Enneking V; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Erwin-Grabner T; Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), University Medical Center Göttingen (UMG), Göttingen, Germany., Evermann U; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany., Fu CHY; University of East London, School of Psychology, London, UK.; Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Fuentes-Claramonte P; FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.; CIBERSAM ISCIII, Madrid, Spain., Godlewska BR; Clinical Psychopharmacology Group, Department of Psychiatry, University of Oxford, Oxford, United Kingdom., Gonul AS; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey.; Mercer University School of Medicine Department of Psychiatry and Behavioral Sciences Macon GA, Macon, USA., Gotlib IH; Department of Psychology, Stanford University, Stanford, USA., Goya-Maldonado R; Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), University Medical Center Göttingen (UMG), Göttingen, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Groenewold NA; Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Grotegerd D; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hall G; Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada., Harrison BJ; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia., Heindel W; University Clinic for Radiology, University of Münster, Münster, Germany., Hermesdorf M; Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany., Ho TC; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Ichikawa N; Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Itai E; Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Jahanshad N; Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Jamalabadi H; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Jamieson AJ; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia., Jansen A; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany.; Core-Facility Brainimagin, Faculty of Medicine, University of Marburg, Marburg, Germany., Kircher T; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Klimes-Dougan B; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Krämer B; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany., Krug A; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Lancaster TM; Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Maindy Road, Cardiff, UK.; Department of Psychology, University of Bath, Claverton Down, Bath, UK., Leehr EJ; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Li M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jena-, Magdeburg, Germany.; Clinical Affective Neuroimaging Laboratory, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany., Linden DEJ; Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.; Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Maindy Road, Cardiff, UK., MacMaster F; IWK Health, NS, Halifax, Canada.; Department of Psychiatry, Dalhousie University, Halifax, Canada., McMahon KL; School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Herston, Australia., Mehler DMA; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Maindy Road, Cardiff, UK.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Mwangi B; Center of Excellence on Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Nenadić I; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Okada G; Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Okamoto Y; Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Opel N; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jena-, Magdeburg, Germany.; German Center for Mental Health (DZPG), partner site Halle-Jena-, Magdeburg, Germany., Pfarr JK; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany.; Origami Lab, Montreal Neurological Institute, McGill, Canada., Pomarol-Clotet E; FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.; CIBERSAM ISCIII, Madrid, Spain., Portella MJ; CIBERSAM ISCIII, Madrid, Spain.; Mental Health Research Group, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Redlich R; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychology, University of Halle, Halle, Germany.; German Center of Mental Health - Halle Site, Halle, Germany., Reneman L; Amsterdam University Medical Centers, location AMC, department of Radiology and Nuclear Medicine, Amsterdam, the Netherlands., Repple J; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Ringwald K; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany., Rodriguez-Cano E; FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.; CIBERSAM ISCIII, Madrid, Spain., Rosa PGP; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brasil., Sacchet MD; Meditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sämann PG; Max Planck Institute of Psychiatry, Munich, Germany., Salvador R; FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain.; CIBERSAM ISCIII, Madrid, Spain., Schrantee A; Amsterdam University Medical Centers, location AMC, department of Radiology and Nuclear Medicine, Amsterdam, the Netherlands., Shinzato H; Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; Department of Neuropsychiatry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan., Sim K; West Region, Institute of Mental Health, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Simulionyte E; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany., Soares JC; Center of Excellence on Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Stein DJ; SAMRC Unit on Risk & Resilience, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Stein F; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Straube B; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Strike LT; QIMR Berghofer Medical Research Institute, Herston, Australia., Thomas-Odenthal F; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Thomopoulos SI; Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Thompson PM; Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., van Tol MJ; University Medical Center Groningen, Cognitive Neuroscience Center, University of Groningen, Groningen, the Netherlands., Usemann P; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany.; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany., Uyar A; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey.; Department of Psychiatry, Muğla Training and Research Hospital, Muğla, Turkey., van der Wee N; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., van der Werff S; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., Vives-Gilabert Y; Intelligent Data Analysis Laboratory, Department of Electronic Engineering, University of Valencia (UV), Valencia, Spain., Völzke H; German Center for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Walter M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jena-, Magdeburg, Germany.; German Center for Mental Health (DZPG), partner site Halle-Jena-, Magdeburg, Germany.; Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany., Whittle S; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Wroblewski A; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Marburg, Germany., Wu MJ; Center of Excellence on Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Yang TT; Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Weill Institute of Neurosciences, UCSF School of Medicine, San Francisco, USA., Zunta-Soares GB; Center of Excellence on Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, USA., Veltman DJ; Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, Netherlands.; Amsterdam Neuroscience, Brain Imaging program, Amsterdam, Netherlands., Schmaal L; Orygen, Parkville, VIC, Australia. lianne.schmaal@unimelb.edu.au.; Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia. lianne.schmaal@unimelb.edu.au., van Velzen LS; Orygen, Parkville, VIC, Australia.; Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Source: Molecular psychiatry [Mol Psychiatry] 2025 Dec; Vol. 30 (12), pp. 5625-5636. Date of Electronic Publication: 2025 Nov 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03310-8