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Multicenter randomized phase II study of R-MPV-A chemoimmunotherapy with or without low-dose whole-brain radiotherapy for newly-diagnosed primary CNS lymphoma.

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Title: Multicenter randomized phase II study of R-MPV-A chemoimmunotherapy with or without low-dose whole-brain radiotherapy for newly-diagnosed primary CNS lymphoma.
Authors: Omuro A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA (A.O.)., DeAngelis LM; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.)., Polley MC; NRG Oncology Statistics and Data Management Center, Chicago, IL, USA (M.-Y.C.P.).; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA (M.-Y.C.P.)., Correa D; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.)., Wefel JS; Department of Neurology, University of Texas MD Anderson Cancer Center, Houston, TX, USA (J.S.W.)., Bovi JA; Department of Radiation Oncology, ThedaCare Regional Cancer Center, Appleton, WI, USA (J.A.B.)., Rosenblum M; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.)., Corn BW; Department of Oncology, Sha'are Zedek Medical Center, Jerusalem, Israel (B.W.C.)., Aneja S; Department of Radiation Oncology, Yale University, New Haven, CT, USA (S.A.)., Grommes C; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.)., Peereboom DM; Department of Medicine, Cleveland Clinic, Cleveland, OH, USA (D.M.P.)., Lallana EC; Department of Neurology, Kaiser Permanente NCI Community Oncology Research Program, Oakland, CA, USA (E.C.L.)., Werner-Wasik M; Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA (M.W.-W.)., Rogers CL; Department of Radiation Oncology, Utah Cancer Specialists, West Jordan, UT, USA (C.L.R.)., Iwamoto FM; Department of Neurology, Columbia University Minority Underserved NCORP, Manhattan, NY, USA (F.M.I.)., Yu HM; Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA (H.-H.M.Y.)., Donnelly ED; Department of Radiation Oncology, Northwestern University, Evanston, IL, USA (E.D.D.)., Struve TD; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA (T.D.S.)., Won M; NRG Oncology Statistics and Data Management Center, Philadelphia, PA, USA (M.W.)., Mehta MP; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA (M.P.M.).
Source: Neuro-oncology [Neuro Oncol] 2026 Feb 01; Vol. 28 (2), pp. 371-382.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multicenter randomized phase II study of R-MPV-A chemoimmunotherapy with or without low-dose whole-brain radiotherapy for newly-diagnosed primary CNS lymphoma.
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  Data: <searchLink fieldCode="AU" term="%22Omuro+A%22">Omuro A</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA (A.O.).<br /><searchLink fieldCode="AU" term="%22DeAngelis+LM%22">DeAngelis LM</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.).<br /><searchLink fieldCode="AU" term="%22Polley+MC%22">Polley MC</searchLink>; NRG Oncology Statistics and Data Management Center, Chicago, IL, USA (M.-Y.C.P.).; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA (M.-Y.C.P.).<br /><searchLink fieldCode="AU" term="%22Correa+D%22">Correa D</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.).<br /><searchLink fieldCode="AU" term="%22Wefel+JS%22">Wefel JS</searchLink>; Department of Neurology, University of Texas MD Anderson Cancer Center, Houston, TX, USA (J.S.W.).<br /><searchLink fieldCode="AU" term="%22Bovi+JA%22">Bovi JA</searchLink>; Department of Radiation Oncology, ThedaCare Regional Cancer Center, Appleton, WI, USA (J.A.B.).<br /><searchLink fieldCode="AU" term="%22Rosenblum+M%22">Rosenblum M</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.).<br /><searchLink fieldCode="AU" term="%22Corn+BW%22">Corn BW</searchLink>; Department of Oncology, Sha'are Zedek Medical Center, Jerusalem, Israel (B.W.C.).<br /><searchLink fieldCode="AU" term="%22Aneja+S%22">Aneja S</searchLink>; Department of Radiation Oncology, Yale University, New Haven, CT, USA (S.A.).<br /><searchLink fieldCode="AU" term="%22Grommes+C%22">Grommes C</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA (L.M.D., D.C., M.R., C.G.).<br /><searchLink fieldCode="AU" term="%22Peereboom+DM%22">Peereboom DM</searchLink>; Department of Medicine, Cleveland Clinic, Cleveland, OH, USA (D.M.P.).<br /><searchLink fieldCode="AU" term="%22Lallana+EC%22">Lallana EC</searchLink>; Department of Neurology, Kaiser Permanente NCI Community Oncology Research Program, Oakland, CA, USA (E.C.L.).<br /><searchLink fieldCode="AU" term="%22Werner-Wasik+M%22">Werner-Wasik M</searchLink>; Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA (M.W.-W.).<br /><searchLink fieldCode="AU" term="%22Rogers+CL%22">Rogers CL</searchLink>; Department of Radiation Oncology, Utah Cancer Specialists, West Jordan, UT, USA (C.L.R.).<br /><searchLink fieldCode="AU" term="%22Iwamoto+FM%22">Iwamoto FM</searchLink>; Department of Neurology, Columbia University Minority Underserved NCORP, Manhattan, NY, USA (F.M.I.).<br /><searchLink fieldCode="AU" term="%22Yu+HM%22">Yu HM</searchLink>; Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA (H.-H.M.Y.).<br /><searchLink fieldCode="AU" term="%22Donnelly+ED%22">Donnelly ED</searchLink>; Department of Radiation Oncology, Northwestern University, Evanston, IL, USA (E.D.D.).<br /><searchLink fieldCode="AU" term="%22Struve+TD%22">Struve TD</searchLink>; Department of Radiation Oncology, University of Cincinnati, Cincinnati, OH, USA (T.D.S.).<br /><searchLink fieldCode="AU" term="%22Won+M%22">Won M</searchLink>; NRG Oncology Statistics and Data Management Center, Philadelphia, PA, USA (M.W.).<br /><searchLink fieldCode="AU" term="%22Mehta+MP%22">Mehta MP</searchLink>; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA (M.P.M.).
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  Data: <searchLink fieldCode="JN" term="%22100887420%22">Neuro-oncology</searchLink> [Neuro Oncol] 2026 Feb 01; Vol. 28 (2), pp. 371-382.
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  Data: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100887420 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1523-5866 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215228517%22">15228517 </searchLink><i>NLM ISO Abbreviation: </i>Neuro Oncol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/neuonc/noaf221
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              Text: 2026 Feb 01
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