Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression.
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| Title: | Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression. |
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| Authors: | Martin MB; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Mousavi F; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Goebel G; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Di Stasi D; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Mano A; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Glogov A; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Zhao L; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Di Guglielmo G; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Shooshtari P; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Children's Health Research Institute, London Health Sciences Centre Research Institute, London, ON, Canada.; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Pin CL; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada. cpin@uwo.ca.; Children's Health Research Institute, London Health Sciences Centre Research Institute, London, ON, Canada. cpin@uwo.ca.; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.; Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca. |
| Source: | Cell death discovery [Cell Death Discov] 2025 Nov 06; Vol. 11 (1), pp. 503. Date of Electronic Publication: 2025 Nov 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2058-7716 |
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| DOI: | 10.1038/s41420-025-02777-2 |
