Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression.

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Title: Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression.
Authors: Martin MB; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Mousavi F; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Goebel G; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Di Stasi D; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Mano A; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada., Glogov A; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Zhao L; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Di Guglielmo G; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Shooshtari P; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Children's Health Research Institute, London Health Sciences Centre Research Institute, London, ON, Canada.; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Pin CL; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada. cpin@uwo.ca.; Children's Health Research Institute, London Health Sciences Centre Research Institute, London, ON, Canada. cpin@uwo.ca.; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.; Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.
Source: Cell death discovery [Cell Death Discov] 2025 Nov 06; Vol. 11 (1), pp. 503. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
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  Data: Acinar-specific loss of activating transcription factor 3 restricts KRAS<superscript>G12D</superscript> mediated transcriptional changes and PanIN progression.
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  Data: <searchLink fieldCode="AU" term="%22Martin+MB%22">Martin MB</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mousavi+F%22">Mousavi F</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Goebel+G%22">Goebel G</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Di+Stasi+D%22">Di Stasi D</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mano+A%22">Mano A</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Glogov+A%22">Glogov A</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Di+Guglielmo+G%22">Di Guglielmo G</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Shooshtari+P%22">Shooshtari P</searchLink>; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Children's Health Research Institute, London Health Sciences Centre Research Institute, London, ON, Canada.; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pin+CL%22">Pin CL</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.; Cancer Research Laboratory Program, London Health Sciences Research Institute and Verspeeten Family Cancer Centre, London, ON, Canada. cpin@uwo.ca.; Children's Health Research Institute, London Health Sciences Centre Research Institute, London, ON, Canada. cpin@uwo.ca.; Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.; Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cpin@uwo.ca.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Nov 06
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