A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens.
Saved in:
| Title: | A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens. |
|---|---|
| Authors: | Urem M; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.; Centre for Microbial Cell Biology, Leiden, The Netherlands., Friggen AH; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands., Musch N; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands., Silverman MH; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Swain CJ; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Barbachyn MR; Calvin University, Grand Rapids, MI, USA., Mortin LI; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Yu X; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., DeLuccia RJ; Acurx Pharmaceuticals, Inc., Staten Island, NY, USA., Lamers MH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands. m.h.lamers@lumc.nl.; NeCEN-Netherlands Centre For Electron Nanoscopy, Leiden, The Netherlands. m.h.lamers@lumc.nl., Smits WK; Leiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands. w.k.smits@lumc.nl.; Centre for Microbial Cell Biology, Leiden, The Netherlands. w.k.smits@lumc.nl. |
| Source: | Nature communications [Nat Commun] 2025 Nov 06; Vol. 16 (1), pp. 9784. Date of Electronic Publication: 2025 Nov 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 2041-1723 |
|---|---|
| DOI: | 10.1038/s41467-025-65324-8 |
