Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology.
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| Title: | Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology. |
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| Authors: | Verkuyl C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Belotserkovsky A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Zerbes T; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Williams D; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Krishnan MR; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Zhu S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Grunnesjӧ S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Eid S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Zhang C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Zhao W; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Xu L; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Lin E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., O'Shea T; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Draper B; Megadalton Solutions, Inc., and Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America., Jungman A; German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany.; Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany., Most P; German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany.; Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany., Schmitt-Ulms G; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada. |
| Source: | PloS one [PLoS One] 2025 Nov 07; Vol. 20 (11), pp. e0336578. Date of Electronic Publication: 2025 Nov 07 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0336578 |
