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Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology.

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Title: Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology.
Authors: Verkuyl C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Belotserkovsky A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Zerbes T; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Williams D; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Krishnan MR; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Zhu S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Grunnesjӧ S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Eid S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Zhang C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Zhao W; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Xu L; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Lin E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., O'Shea T; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Draper B; Megadalton Solutions, Inc., and Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America., Jungman A; German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany.; Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany., Most P; German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany.; Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany., Schmitt-Ulms G; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Source: PloS one [PLoS One] 2025 Nov 07; Vol. 20 (11), pp. e0336578. Date of Electronic Publication: 2025 Nov 07 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology.
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  Data: <searchLink fieldCode="AU" term="%22Verkuyl+C%22">Verkuyl C</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Belotserkovsky+A%22">Belotserkovsky A</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zerbes+T%22">Zerbes T</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Williams+D%22">Williams D</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Krishnan+MR%22">Krishnan MR</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhu+S%22">Zhu S</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Grunnesjӧ+S%22">Grunnesjӧ S</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Eid+S%22">Eid S</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+E%22">Lin E</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22O'Shea+T%22">O'Shea T</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Draper+B%22">Draper B</searchLink>; Megadalton Solutions, Inc., and Department of Chemistry, Indiana University, Bloomington, Indiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Jungman+A%22">Jungman A</searchLink>; German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany.; Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Most+P%22">Most P</searchLink>; German Centre for Cardiovascular Research (DZHK), Heidelberg, Germany.; Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitt-Ulms+G%22">Schmitt-Ulms G</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.
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