TH17 cells converted into exTH17 cells sustain rheumatoid-like IL-17-independent inflammatory arthritis.
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| Authors: | Zoccheddu M; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093, USA., Suga K; Department of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Seng A; Department of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Svensson MND; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg 41346, Sweden., Dutta P; Centers for Autoimmunity, Inflammation and Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Panahandeh S; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Makinde HM; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Ro M; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Wang Y; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Kim H; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Mikulski Z; Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Dobaczewska K; Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Ingegnoli F; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy., Minsha R; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Seagrist JF; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Carns M; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Aren K; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dominguez S; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Khan MD; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Denn A; Histology and Microscopy Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Caporali R; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy., Randelli PS; 1st Orthopedic Unit, ASST Gaetano Pini-CTO, Lab of Applied Biomechanics, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy., McBride DA; Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA., Mandelin AM 2nd; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Cuda CM; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Wang ZP; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Moore JH; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Shah NJ; Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA., Won KJ; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Winter DR; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Ay F; Centers for Autoimmunity, Inflammation and Cancer Immunotherapy, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Perlman H; Department of Medicine, Division of Rheumatology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Bottini N; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Medicine, Kao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. |
| Source: | Science immunology [Sci Immunol] 2025 Nov 07; Vol. 10 (113), pp. eadm7800. Date of Electronic Publication: 2025 Nov 07. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adm7800 |
