A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression.

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Title: A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression.
Authors: Hack LM; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA., Jubeir J; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Hilton R; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Tozzi L; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Boyar L; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Zhang X; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Lyons T; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Jo B; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., O'Hara R; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA., Schatzberg AF; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Williams LM; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA.
Source: Nature. Mental health [Nat Ment Health] 2025; Vol. 3 (11), pp. 1363-1373. Date of Electronic Publication: 2025 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918486688806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-6076 (Electronic) Linking ISSN: 27316076 NLM ISO Abbreviation: Nat Ment Health Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-6076
DOI:10.1038/s44220-025-00510-7