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A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression.

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Title: A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression.
Authors: Hack LM; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA., Jubeir J; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Hilton R; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Tozzi L; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Boyar L; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Zhang X; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Lyons T; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Jo B; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., O'Hara R; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA., Schatzberg AF; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA., Williams LM; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA.
Source: Nature. Mental health [Nat Ment Health] 2025; Vol. 3 (11), pp. 1363-1373. Date of Electronic Publication: 2025 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918486688806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-6076 (Electronic) Linking ISSN: 27316076 NLM ISO Abbreviation: Nat Ment Health Subsets: PubMed not MEDLINE
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  Data: A stratified precision medicine trial targeting α<subscript>2A</subscript>-adrenergic receptor agonism as a treatment for the cognitive biotype of depression.
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  Data: <searchLink fieldCode="AU" term="%22Hack+LM%22">Hack LM</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA.<br /><searchLink fieldCode="AU" term="%22Jubeir+J%22">Jubeir J</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22Hilton+R%22">Hilton R</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22Tozzi+L%22">Tozzi L</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22Boyar+L%22">Boyar L</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22Lyons+T%22">Lyons T</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22Jo+B%22">Jo B</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22O'Hara+R%22">O'Hara R</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA.<br /><searchLink fieldCode="AU" term="%22Schatzberg+AF%22">Schatzberg AF</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.<br /><searchLink fieldCode="AU" term="%22Williams+LM%22">Williams LM</searchLink>; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA USA.; Sierra Pacific Mental Illness Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA USA.
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  Data: <searchLink fieldCode="JN" term="%229918486688806676%22">Nature. Mental health</searchLink> [Nat Ment Health] 2025; Vol. 3 (11), pp. 1363-1373. <i>Date of Electronic Publication: </i>2025 Oct 13.
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              Text: 2025
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