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A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins.

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Title: A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins.
Authors: He S; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Meister D; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Khan S; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Mohammadzadeh A; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Delgadillo Silva L; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Rutter GA; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Diabetes, Endocrinology and Medicine, Faculty of Medicine, Imperial College, London, UK.; LKC School of Medicine, Nanyang Technological College, Singapore, Republic of Singapore.; Research Institute of the McGill University Health Centre, Montreal, Canada., Trant JF; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.; WE-Spark Health Institute, Windsor, ON, Canada.; Binary Star Research Services, LaSalle, ON, Canada.; Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada., Lim GE; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. gareth.lim@umontreal.ca.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. gareth.lim@umontreal.ca.
Source: Cell death & disease [Cell Death Dis] 2025 Nov 10; Vol. 16 (1), pp. 825. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins.
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  Data: <searchLink fieldCode="AU" term="%22He+S%22">He S</searchLink>; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Meister+D%22">Meister D</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Khan+S%22">Khan S</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mohammadzadeh+A%22">Mohammadzadeh A</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Delgadillo+Silva+L%22">Delgadillo Silva L</searchLink>; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Rutter+GA%22">Rutter GA</searchLink>; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Diabetes, Endocrinology and Medicine, Faculty of Medicine, Imperial College, London, UK.; LKC School of Medicine, Nanyang Technological College, Singapore, Republic of Singapore.; Research Institute of the McGill University Health Centre, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Trant+JF%22">Trant JF</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.; WE-Spark Health Institute, Windsor, ON, Canada.; Binary Star Research Services, LaSalle, ON, Canada.; Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lim+GE%22">Lim GE</searchLink>; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. gareth.lim@umontreal.ca.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. gareth.lim@umontreal.ca.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2025 Nov 10; Vol. 16 (1), pp. 825. <i>Date of Electronic Publication: </i>2025 Nov 10.
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              Text: 2025 Nov 10
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