A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins.
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| Title: | A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins. |
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| Authors: | He S; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Meister D; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Khan S; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Mohammadzadeh A; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada., Delgadillo Silva L; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Rutter GA; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Diabetes, Endocrinology and Medicine, Faculty of Medicine, Imperial College, London, UK.; LKC School of Medicine, Nanyang Technological College, Singapore, Republic of Singapore.; Research Institute of the McGill University Health Centre, Montreal, Canada., Trant JF; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.; WE-Spark Health Institute, Windsor, ON, Canada.; Binary Star Research Services, LaSalle, ON, Canada.; Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada., Lim GE; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. gareth.lim@umontreal.ca.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. gareth.lim@umontreal.ca. |
| Source: | Cell death & disease [Cell Death Dis] 2025 Nov 10; Vol. 16 (1), pp. 825. Date of Electronic Publication: 2025 Nov 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| FullText | Links: – Type: pdflink Text: Availability: 1 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41213973 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22He+S%22">He S</searchLink>; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Meister+D%22">Meister D</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Khan+S%22">Khan S</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mohammadzadeh+A%22">Mohammadzadeh A</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Delgadillo+Silva+L%22">Delgadillo Silva L</searchLink>; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Rutter+GA%22">Rutter GA</searchLink>; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Diabetes, Endocrinology and Medicine, Faculty of Medicine, Imperial College, London, UK.; LKC School of Medicine, Nanyang Technological College, Singapore, Republic of Singapore.; Research Institute of the McGill University Health Centre, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Trant+JF%22">Trant JF</searchLink>; Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.; WE-Spark Health Institute, Windsor, ON, Canada.; Binary Star Research Services, LaSalle, ON, Canada.; Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lim+GE%22">Lim GE</searchLink>; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. gareth.lim@umontreal.ca.; Cardiometabolic axis, Centre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. gareth.lim@umontreal.ca. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2025 Nov 10; Vol. 16 (1), pp. 825. <i>Date of Electronic Publication: </i>2025 Nov 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41419-025-08150-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 825 Titles: – TitleFull: A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: He S – PersonEntity: Name: NameFull: Meister D – PersonEntity: Name: NameFull: Khan S – PersonEntity: Name: NameFull: Mohammadzadeh A – PersonEntity: Name: NameFull: Delgadillo Silva L – PersonEntity: Name: NameFull: Rutter GA – PersonEntity: Name: NameFull: Trant JF – PersonEntity: Name: NameFull: Lim GE IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 11 Text: 2025 Nov 10 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-4889 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Cell death & disease Type: main |
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