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Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes.

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Title: Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes.
Authors: Tranfa M; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands. m.tranfa@amsterdamumc.nl.; Department of Advanced Biomedical Sciences, University of Naples 'Federico II', Via Pansini 5, Naples, 80131, Italy. m.tranfa@amsterdamumc.nl., Pieperhoff L; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Amsterdam Neuroscience, Brain Imaging, De Boelelaan 1085, Amsterdam, 1081HV, Netherlands., Pontillo G; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Department of Advanced Biomedical Sciences, University of Naples 'Federico II', Via Pansini 5, Naples, 80131, Italy.; Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.; Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC , Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands., Luckett ES; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Laboratory for Cognitive Neurology, Leuven Brain Institute, KU Leuven, ON5, Herestraat 49, Leuven, 3001, Belgium.; Laboratory for Complex Genetics, KU Leuven, ON6, Herestraat 49, 610, Leuven, Belgium., Collij LE; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Amsterdam Neuroscience, Brain Imaging, De Boelelaan 1085, Amsterdam, 1081HV, Netherlands.; Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, St Johannesgatan 8, Malmö, 211 46, Sweden., Oliveira TG; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, Braga, 4710-057, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Campus Gualtar, Braga, Guimarães, 4710-057, Portugal.; Department of Neuroradiology, ULS/Hospital de Braga, Braga, 4710-243, Portugal., Tesi N; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Amsterdam UMC location VUmc, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Van Mourik Broekmanweg 6, Delft, 2628 XE, Netherlands., Vilor-Tejedor N; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Calle Wellington 30, Barcelona, 08005, Spain.; Hospital del Mar Medical Research Institute, Doctor Aiguader 88, Barcelona, 08003, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Carrer del Doctor Aiguader, 88, Ciutat Vella, Barcelona, 08003, Spain.; Department of Human Genetics, Radboud University Medical Center, Geert Grooteplein-Zuid 10, Nijmegen, 6525 GA, Netherlands., Altmann A; Department of Medical Physics, UCL Hawkes Institute, University College London, 90 High Holborn, London, WC1E 6BT, UK., Roccatagliata L; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa, 16132, Italy.; Department of Health Sciences (DISSAL), University of Genoa, Via Antonio Pastore 1, Genoa, 16132, Italy., Pardini M; IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, Genoa, 16132, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Paolo Daneo, 3, Genoa, 16132, Italy., Holstege H; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Amsterdam UMC location VUmc, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Vlaams Instituut voor Biotechnologie Center for Brain and Disease Research, ON5, Herestraat 49, Leuven, 3001, Belgium.; Department of Neurosciences, Leuven Brain Institute, KU Leuven, Onderwijs en Navorsing 5, Herestraat, box 1020, Leuven, 3000, Belgium., Reinders M; Delft Bioinformatics Lab, Delft University of Technology, Van Mourik Broekmanweg 6, Delft, 2628 XE, Netherlands., Payoux P; Department of Nuclear Medicine, Toulouse University Hospital, 2 Rue Charles Viguerie, Toulouse, 31300, France.; Toulouse NeuroImaging Center, ToNIC, Inserm, UPS, University of Toulouse, Place du Dr Joseph Baylac, Toulouse, 31024, France., Martinez-Lage P; Centro de Investigación y Terapias Avanzadas, Neurología, CITA-Alzheimer Foundation, , Mikeletegi Pasealekua, 71, 1, Donostia, San Sebastián, 20009, Spain., Ritchie CW; Outpatient Department 2, Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, Western General Hospital, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK.; Brain Health Scotland, 160 Dundee Street, Edinburgh, EH11 1DQ, UK., Waldman A; Centre for Clinical Brain Sciences, The University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; Department of Medicine, Imperial College London, Ayrton Road, South Kensington, London, SW7 5NH, UK., Wardlaw JM; Centre for Clinical Brain Sciences, The University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; UK Dementia Research Institute Centre at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK., Gispert JD; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Calle Wellington 30, Barcelona, 08005, Spain.; Hospital del Mar Medical Research Institute, Doctor Aiguader 88, Barcelona, 08003, Spain.; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Monforte de Lemos, 3-5, Madrid, 28029, Spain.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fernández Almagro 3, Madrid, 28029, Spain., Salvadó G; Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, St Johannesgatan 8, Malmö, 211 46, Sweden., Brunetti A; Department of Advanced Biomedical Sciences, University of Naples 'Federico II', Via Pansini 5, Naples, 80131, Italy., Mutsaerts HJMM; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Amsterdam Neuroscience, Brain Imaging, De Boelelaan 1085, Amsterdam, 1081HV, Netherlands., Wink AM; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Amsterdam Neuroscience, Brain Imaging, De Boelelaan 1085, Amsterdam, 1081HV, Netherlands., Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.; Department of Medical Physics, UCL Hawkes Institute, University College London, 90 High Holborn, London, WC1E 6BT, UK.; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3AR, UK., Lorenzini L; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands.; Amsterdam Neuroscience, Brain Imaging, De Boelelaan 1085, Amsterdam, 1081HV, Netherlands.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Paolo Daneo, 3, Genoa, 16132, Italy.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Nov 10; Vol. 17 (1), pp. 240. Date of Electronic Publication: 2025 Nov 10.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1758-9193
DOI:10.1186/s13195-025-01888-3