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Increasing inflammatory biomarkers are associated with mortality in critically ill COVID-19 patients despite anti-inflammatory treatment.

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Title: Increasing inflammatory biomarkers are associated with mortality in critically ill COVID-19 patients despite anti-inflammatory treatment.
Authors: Daenen K; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. k.daenen@erasmusmc.nl.; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. k.daenen@erasmusmc.nl., Rizopoulos D; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Dalm VASH; Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands., Huijben JA; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands., Stoof SCM; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands., Nagtzaam NMA; Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands., Dik WA; Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Laboratory Medical Immunology, Reinier Haga Medisch Diagnostisch Centrum (RHMDC), Delft, The Netherlands., Swagemakers SMA; Department of Pathology & Clinical Bioinformatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., van der Spek PJ; Department of Pathology & Clinical Bioinformatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., Tong-Minh K; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands., Mersha DGA; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands., Khyali J; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands., Juffermans NP; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Gommers D; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands., van Gorp ECM; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Bos LDJ; Department of Intensive Care, Location Academic Medical Centre, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Location Academic Medical Centre, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Endeman H; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Intensive Care, OLVG, Amsterdam, The Netherlands.
Source: Clinical and experimental medicine [Clin Exp Med] 2025 Nov 11; Vol. 25 (1), pp. 361. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Increasing inflammatory biomarkers are associated with mortality in critically ill COVID-19 patients despite anti-inflammatory treatment.
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  Data: <searchLink fieldCode="AU" term="%22Daenen+K%22">Daenen K</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. k.daenen@erasmusmc.nl.; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. k.daenen@erasmusmc.nl.<br /><searchLink fieldCode="AU" term="%22Rizopoulos+D%22">Rizopoulos D</searchLink>; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dalm+VASH%22">Dalm VASH</searchLink>; Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Huijben+JA%22">Huijben JA</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Stoof+SCM%22">Stoof SCM</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nagtzaam+NMA%22">Nagtzaam NMA</searchLink>; Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dik+WA%22">Dik WA</searchLink>; Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Laboratory Medical Immunology, Reinier Haga Medisch Diagnostisch Centrum (RHMDC), Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Swagemakers+SMA%22">Swagemakers SMA</searchLink>; Department of Pathology & Clinical Bioinformatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Spek+PJ%22">van der Spek PJ</searchLink>; Department of Pathology & Clinical Bioinformatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tong-Minh+K%22">Tong-Minh K</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mersha+DGA%22">Mersha DGA</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Khyali+J%22">Khyali J</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Juffermans+NP%22">Juffermans NP</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gommers+D%22">Gommers D</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Gorp+ECM%22">van Gorp ECM</searchLink>; Department of Viroscience, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bos+LDJ%22">Bos LDJ</searchLink>; Department of Intensive Care, Location Academic Medical Centre, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Location Academic Medical Centre, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Endeman+H%22">Endeman H</searchLink>; Department of Intensive Care, Erasmus University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Department of Intensive Care, OLVG, Amsterdam, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22100973405%22">Clinical and experimental medicine</searchLink> [Clin Exp Med] 2025 Nov 11; Vol. 25 (1), pp. 361. <i>Date of Electronic Publication: </i>2025 Nov 11.
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