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Single-cell transcriptome profiling of post-treatment and treatment-naïve colorectal cancer: Insights into putative mechanisms of chemoresistance.

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Title: Single-cell transcriptome profiling of post-treatment and treatment-naïve colorectal cancer: Insights into putative mechanisms of chemoresistance.
Authors: Puzanov GA; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France. Electronic address: grigorypuzanov@gmail.com., Astier C; ERC Chromatin Remodeling, DNA Repair and Epigenetics Laboratory, INSERM U981, Gustave Roussy, Villejuif, France; Université Paris-Saclay, Université Paris-Sud XI, Faculté de Médicine, Le Kremlin Bicêtre, France., Papakonstantinou D; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France., Quiroga Londoño M; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France., Blériot C; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France., Yurchenko AA; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France., Bani MA; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France., Jules-Clement G; Gustave Roussy, Université Paris-Saclay, Bioinformatics Core Facility, Inserm US23, CNRS UMS 3655, Villejuif, France., Andre F; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France., Marabelle A; Laboratoire de Recherche Translationnelle en Immunotherapie (LRTI), INSERM U1015, Villejuif, France; Centre d'Investigation Clinique BIOTHERIS, INSERM CIC1428, Villejuif, France; Département d'Innovation Thérapeutique et d'Essais Précoces (DITEP), INSERM U1015, Villejuif, France; Faculté de Médecine, Université Paris Saclay, Le Kremlin Bicêtre, France., Hollebecque A; Gustave Roussy, Department of Medical Oncology, Villejuif, France; Gustave Roussy, Early Drug Development Department (DITEP), Villejuif, France., Nikolaev SI; Université Paris-Saclay, Gustave Roussy, Inserm U981, Villejuif, France. Electronic address: Sergey.Nikolaev@gustaveroussy.fr.
Source: Cancer letters [Cancer Lett] 2026 Jan 01; Vol. 636, pp. 218127. Date of Electronic Publication: 2025 Nov 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7980
DOI:10.1016/j.canlet.2025.218127