Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome.

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Title: Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome.
Authors: Sharma Y; National Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India.; Centre for Doctoral Studies, Manipal Academy of Higher Education, Manipal, 576104, India., Bhatia P; National Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, 10115, Berlin, Germany., Rangappa G; National Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India., Saha S; National Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India.; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, 02111, USA., Raghu P; National Centre for Biological Sciences-TIFR, GKVK Campus, Bangalore, 560065, India. praghu@ncbs.res.in.
Source: EMBO molecular medicine [EMBO Mol Med] 2025 Dec; Vol. 17 (12), pp. 3407-3439. Date of Electronic Publication: 2025 Nov 11.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-025-00327-y