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Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells.

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Title: Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells.
Authors: Salles G; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil., Almeida CAF; School of Pharmaceutical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil., de Carvalho Alves I; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil., de Assis Braz G; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil., Lopes FB; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil., Fernandes JPDS; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil., Chagas-Paula DA; Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil., Katchborian-Neto A; Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil., Alves MF; Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil., Bruno V; School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, São Paulo, Brazil., Paranhos BAPB; School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, São Paulo, Brazil., Marcourakis T; School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, São Paulo, Brazil., Torres LHL; School of Pharmaceutical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil., Garcia RCT; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil. raphael.garcia@unifesp.br.
Source: Archives of toxicology [Arch Toxicol] 2026 Feb; Vol. 100 (2), pp. 603-617. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells.
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  Data: <searchLink fieldCode="AU" term="%22Salles+G%22">Salles G</searchLink>; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Almeida+CAF%22">Almeida CAF</searchLink>; School of Pharmaceutical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Carvalho+Alves+I%22">de Carvalho Alves I</searchLink>; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Assis+Braz+G%22">de Assis Braz G</searchLink>; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Lopes+FB%22">Lopes FB</searchLink>; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Fernandes+JPDS%22">Fernandes JPDS</searchLink>; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Chagas-Paula+DA%22">Chagas-Paula DA</searchLink>; Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Katchborian-Neto+A%22">Katchborian-Neto A</searchLink>; Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+MF%22">Alves MF</searchLink>; Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Bruno+V%22">Bruno V</searchLink>; School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Paranhos+BAPB%22">Paranhos BAPB</searchLink>; School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Marcourakis+T%22">Marcourakis T</searchLink>; School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Torres+LHL%22">Torres LHL</searchLink>; School of Pharmaceutical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Garcia+RCT%22">Garcia RCT</searchLink>; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo (Unifesp), Diadema, São Paulo, Brazil. raphael.garcia@unifesp.br.
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