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Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti-inflammatory agents: In-silico, in-vitro, and in-vivo studies.

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Title: Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti-inflammatory agents: In-silico, in-vitro, and in-vivo studies.
Authors: Rizk HF; Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt., Beltagy DM; Department of Biochemistry, Faculty of Science, Damanhour University, Damanhour 31111, Egypt., Ibrahim SA; Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt., El-Sayed HM; Department of Zoology, Faculty of Science, Damanhour University, Damanhour 31111, Egypt., Fares AK; Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt., Salem MM; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt. Electronic address: maha_salem@science.tanta.edu.eg.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109205. Date of Electronic Publication: 2025 Nov 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Newly synthesized pyranopyrazole nicotinamides derivatives as potent anti-inflammatory agents: In-silico, in-vitro, and in-vivo studies.
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  Data: <searchLink fieldCode="AU" term="%22Rizk+HF%22">Rizk HF</searchLink>; Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt.<br /><searchLink fieldCode="AU" term="%22Beltagy+DM%22">Beltagy DM</searchLink>; Department of Biochemistry, Faculty of Science, Damanhour University, Damanhour 31111, Egypt.<br /><searchLink fieldCode="AU" term="%22Ibrahim+SA%22">Ibrahim SA</searchLink>; Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+HM%22">El-Sayed HM</searchLink>; Department of Zoology, Faculty of Science, Damanhour University, Damanhour 31111, Egypt.<br /><searchLink fieldCode="AU" term="%22Fares+AK%22">Fares AK</searchLink>; Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt.<br /><searchLink fieldCode="AU" term="%22Salem+MM%22">Salem MM</searchLink>; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt. Electronic address: maha_salem@science.tanta.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109205. <i>Date of Electronic Publication: </i>2025 Nov 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bioorg.2025.109205
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              Text: 2025 Dec
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