Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates.

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Title: Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates.
Authors: Dreier JE; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen 2100 Copenhagen Denmark celine.galvagnion@sund.ku.dk., Stevenson A; Department of Biology, Institute of Biochemistry, ETH Zurich Otto Stern Weg 3 8093 Zurich Switzerland thomas.michaels@bc.biol.ethz.ch.; Bringing Materials to Life (BML) Initiative, ETH Zurich Switzerland., Carles E; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen 2100 Copenhagen Denmark celine.galvagnion@sund.ku.dk., Schott K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen 2100 Copenhagen Denmark celine.galvagnion@sund.ku.dk., Michaels TCT; Department of Biology, Institute of Biochemistry, ETH Zurich Otto Stern Weg 3 8093 Zurich Switzerland thomas.michaels@bc.biol.ethz.ch.; Bringing Materials to Life (BML) Initiative, ETH Zurich Switzerland., Galvagnion C; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen 2100 Copenhagen Denmark celine.galvagnion@sund.ku.dk.
Source: Chemical science [Chem Sci] 2025 Oct 31; Vol. 17 (1), pp. 354-363. Date of Electronic Publication: 2025 Oct 31 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-6520
DOI:10.1039/d5sc06116d