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TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis.

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Title: TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis.
Authors: Park KR; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Le MX; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Sul OJ; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea., Jeon J; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Kwon MS; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Lee H; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea., Ra SW; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea; Department of Pulmonary and Critical Care Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea., Kwon HN; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea., Cho WJ; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea. Electronic address: wjcho26@ulsan.ac.kr., Park JW; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea. Electronic address: jwpark@ulsan.ac.kr.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118772. Date of Electronic Publication: 2025 Nov 15.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TTP enhances the sensitivity of KRAS<superscript>G12C</superscript>-mutated lung cancer cells to KRAS<superscript>G12C</superscript> inhibitors by downregulating SLC7A11 and promoting ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Park+KR%22">Park KR</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Le+MX%22">Le MX</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Sul+OJ%22">Sul OJ</searchLink>; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+J%22">Jeon J</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+MS%22">Kwon MS</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Ra+SW%22">Ra SW</searchLink>; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea; Department of Pulmonary and Critical Care Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+HN%22">Kwon HN</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Cho+WJ%22">Cho WJ</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea. Electronic address: wjcho26@ulsan.ac.kr.<br /><searchLink fieldCode="AU" term="%22Park+JW%22">Park JW</searchLink>; Department of Biological Sciences, University of Ulsan, Ulsan, South Korea; Basic-Clinic Convergence Research Institute, University of Ulsan, Ulsan, South Korea. Electronic address: jwpark@ulsan.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118772. <i>Date of Electronic Publication: </i>2025 Nov 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.biopha.2025.118772
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        Text: English
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      – TitleFull: TTP enhances the sensitivity of KRASG12C-mutated lung cancer cells to KRASG12C inhibitors by downregulating SLC7A11 and promoting ferroptosis.
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              Text: 2025 Dec
              Type: published
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