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Therapeutic remodeling of the ceramide backbone prevents kidney injury.

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Title: Therapeutic remodeling of the ceramide backbone prevents kidney injury.
Authors: Nicholson RJ; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Cedeño-Rosario L; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Maschek JA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Metabolomics Core Facility, University of Utah, Salt Lake City, UT, USA., Lonergan T; Metabolomics Core Facility, University of Utah, Salt Lake City, UT, USA., Van Vranken JG; Department of Cell Biology, Harvard Medical School, Cambridge, MA, USA., Kruse ARS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Stubben CJ; Cancer Bioinformatics Resource, University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA., Wang L; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Stuart D; Division of Nephrology and Hypertension, University of Utah Health Department of Internal Medicine, Salt Lake City, UT, USA., Alcantara QA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Revelo MP; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA., Rutter K; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Pahulu M; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Taloa J; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Wu X; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Kim J; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Kim J; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Hall I; Division of Nephrology and Hypertension, University of Utah Health Department of Internal Medicine, Salt Lake City, UT, USA., Clark AJ; Division of Nephrology, University of Texas Southwestern Medical Center Department of Medicine, Dallas, TX, USA; Division of Nephrology, University of Texas Southwestern Medical Center Department of Pediatrics, Dallas, TX, USA., Parikh S; Division of Nephrology, University of Texas Southwestern Medical Center Department of Medicine, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Spraggins J; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Romero D; Centaurus Therapeutics, Inc., San Francisco, CA, USA., Blitzer JT; Centaurus Therapeutics, Inc., San Francisco, CA, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Cambridge, MA, USA., Rutter J; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA; Howard Hughes Medical Institute, Salt Lake City, UT, USA., Holland WL; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA., Ramkumar N; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Division of Nephrology and Hypertension, University of Utah Health Department of Internal Medicine, Salt Lake City, UT, USA., Summers SA; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA. Electronic address: scott.a.summers@health.utah.edu.
Source: Cell metabolism [Cell Metab] 2026 Jan 06; Vol. 38 (1), pp. 135-156.e10. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nicholson+RJ%22">Nicholson RJ</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Cedeño-Rosario+L%22">Cedeño-Rosario L</searchLink>; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Maschek+JA%22">Maschek JA</searchLink>; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Metabolomics Core Facility, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Lonergan+T%22">Lonergan T</searchLink>; Metabolomics Core Facility, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Van+Vranken+JG%22">Van Vranken JG</searchLink>; 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Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Romero+D%22">Romero D</searchLink>; Centaurus Therapeutics, Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blitzer+JT%22">Blitzer JT</searchLink>; Centaurus Therapeutics, Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gygi+SP%22">Gygi SP</searchLink>; Department of Cell Biology, Harvard Medical School, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+J%22">Rutter J</searchLink>; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA; Howard Hughes Medical Institute, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Holland+WL%22">Holland WL</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Ramkumar+N%22">Ramkumar N</searchLink>; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA; Division of Nephrology and Hypertension, University of Utah Health Department of Internal Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Summers+SA%22">Summers SA</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT, USA; Diabetes and Metabolism Research Center, University of Utah College of Medicine, Salt Lake City, UT, USA. Electronic address: scott.a.summers@health.utah.edu.
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