Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors.
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| Title: | Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors. |
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| Authors: | Wang X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Xuefeng.Wang@moffitt.org., Li T; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Eljilany I; Departments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Soupir A; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Radmacher M; Aster Insights, Hudson, FL, USA., Agius P; Aster Insights, Hudson, FL, USA., Sukrithan V; Department of Internal Medicine, Ohio State University and Arthur G James Comprehensive Cancer Center, Columbus, OH, USA., Ratan A; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA., McCarter M; Department of Surgery, University of Colorado Cancer Center, Aurora, CO, USA., Salhia B; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Colman H; Department of Neurosurgery, School of Medicine, University of Utah, Salt Lake City, UT, USA., Naqash AR; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Puzanov I; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Arnold S; Department of Medical Oncology, University of Kentucky Markey Cancer Center, Lexington, KY, USA., Marin-Acevedo JA; Medical Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA., Ganesan S; Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Churchman M; Aster Insights, Hudson, FL, USA., Hwu P; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Dalton WS; Aster Insights, Hudson, FL, USA., Weiner GJ; Department of Internal Medicine, Carver College of Medicine, University of Iowa Health Care, Iowa City, IA, USA., Tarhini AA; Departments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Ahmad.Tarhini@moffitt.org. |
| Source: | Nature communications [Nat Commun] 2025 Nov 13; Vol. 16 (1), pp. 9968. Date of Electronic Publication: 2025 Nov 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65016-3 |
