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Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors.

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Title: Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors.
Authors: Wang X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Xuefeng.Wang@moffitt.org., Li T; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Eljilany I; Departments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Soupir A; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Radmacher M; Aster Insights, Hudson, FL, USA., Agius P; Aster Insights, Hudson, FL, USA., Sukrithan V; Department of Internal Medicine, Ohio State University and Arthur G James Comprehensive Cancer Center, Columbus, OH, USA., Ratan A; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA., McCarter M; Department of Surgery, University of Colorado Cancer Center, Aurora, CO, USA., Salhia B; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Colman H; Department of Neurosurgery, School of Medicine, University of Utah, Salt Lake City, UT, USA., Naqash AR; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Puzanov I; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Arnold S; Department of Medical Oncology, University of Kentucky Markey Cancer Center, Lexington, KY, USA., Marin-Acevedo JA; Medical Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA., Ganesan S; Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Churchman M; Aster Insights, Hudson, FL, USA., Hwu P; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Dalton WS; Aster Insights, Hudson, FL, USA., Weiner GJ; Department of Internal Medicine, Carver College of Medicine, University of Iowa Health Care, Iowa City, IA, USA., Tarhini AA; Departments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Ahmad.Tarhini@moffitt.org.
Source: Nature communications [Nat Commun] 2025 Nov 13; Vol. 16 (1), pp. 9968. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Xuefeng.Wang@moffitt.org.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Eljilany+I%22">Eljilany I</searchLink>; Departments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Soupir+A%22">Soupir A</searchLink>; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Radmacher+M%22">Radmacher M</searchLink>; Aster Insights, Hudson, FL, USA.<br /><searchLink fieldCode="AU" term="%22Agius+P%22">Agius P</searchLink>; Aster Insights, Hudson, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sukrithan+V%22">Sukrithan V</searchLink>; Department of Internal Medicine, Ohio State University and Arthur G James Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ratan+A%22">Ratan A</searchLink>; Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22McCarter+M%22">McCarter M</searchLink>; Department of Surgery, University of Colorado Cancer Center, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Salhia+B%22">Salhia B</searchLink>; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Colman+H%22">Colman H</searchLink>; Department of Neurosurgery, School of Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Naqash+AR%22">Naqash AR</searchLink>; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Puzanov+I%22">Puzanov I</searchLink>; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+S%22">Arnold S</searchLink>; Department of Medical Oncology, University of Kentucky Markey Cancer Center, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Marin-Acevedo+JA%22">Marin-Acevedo JA</searchLink>; Medical Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Ganesan+S%22">Ganesan S</searchLink>; Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Churchman+M%22">Churchman M</searchLink>; Aster Insights, Hudson, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hwu+P%22">Hwu P</searchLink>; H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+PC%22">Rodriguez PC</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Dalton+WS%22">Dalton WS</searchLink>; Aster Insights, Hudson, FL, USA.<br /><searchLink fieldCode="AU" term="%22Weiner+GJ%22">Weiner GJ</searchLink>; Department of Internal Medicine, Carver College of Medicine, University of Iowa Health Care, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Tarhini+AA%22">Tarhini AA</searchLink>; Departments of Cutaneous Oncology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Ahmad.Tarhini@moffitt.org.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 13; Vol. 16 (1), pp. 9968. <i>Date of Electronic Publication: </i>2025 Nov 13.
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