Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.

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Title: Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.
Authors: van der Plas-van Duijn A; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Winkelman LMT; Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Lensen C; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Duivendijk M; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., Derksen I; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Veenendaal JMF; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., Schaap G; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Sluijter M; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., van Groningen TJB; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Doorn R; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Hall T; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Slieker RC; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Sharp TH; School of Biochemistry, University of Bristol, Bristol, United Kingdom., Beltman JB; Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Bresser K; T Cell Differentiation Lab, Department of Research, Sanquin Blood Supply Foundation, Amsterdam, the Netherlands., Scheeren FA; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. f.a.scheeren@lumc.nl.
Source: Communications biology [Commun Biol] 2025 Nov 13; Vol. 8 (1), pp. 1561. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2399-3642
DOI:10.1038/s42003-025-08938-4