Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.

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Title: Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.
Authors: van der Plas-van Duijn A; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Winkelman LMT; Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Lensen C; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Duivendijk M; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., Derksen I; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Veenendaal JMF; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., Schaap G; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Sluijter M; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., van Groningen TJB; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Doorn R; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands., van Hall T; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Slieker RC; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands., Sharp TH; School of Biochemistry, University of Bristol, Bristol, United Kingdom., Beltman JB; Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Bresser K; T Cell Differentiation Lab, Department of Research, Sanquin Blood Supply Foundation, Amsterdam, the Netherlands., Scheeren FA; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. f.a.scheeren@lumc.nl.
Source: Communications biology [Commun Biol] 2025 Nov 13; Vol. 8 (1), pp. 1561. Date of Electronic Publication: 2025 Nov 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
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  Data: Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.
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  Data: <searchLink fieldCode="AU" term="%22van+der+Plas-van+Duijn+A%22">van der Plas-van Duijn A</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Winkelman+LMT%22">Winkelman LMT</searchLink>; Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lensen+C%22">Lensen C</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Duivendijk+M%22">van Duivendijk M</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Derksen+I%22">Derksen I</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Veenendaal+JMF%22">van Veenendaal JMF</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schaap+G%22">Schaap G</searchLink>; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sluijter+M%22">Sluijter M</searchLink>; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Groningen+TJB%22">van Groningen TJB</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Doorn+R%22">van Doorn R</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Hall+T%22">van Hall T</searchLink>; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Slieker+RC%22">Slieker RC</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medical Oncology, Oncode institute, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sharp+TH%22">Sharp TH</searchLink>; School of Biochemistry, University of Bristol, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Beltman+JB%22">Beltman JB</searchLink>; Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bresser+K%22">Bresser K</searchLink>; T Cell Differentiation Lab, Department of Research, Sanquin Blood Supply Foundation, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Scheeren+FA%22">Scheeren FA</searchLink>; Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands. f.a.scheeren@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2025 Nov 13; Vol. 8 (1), pp. 1561. <i>Date of Electronic Publication: </i>2025 Nov 13.
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