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Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis.

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Title: Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis.
Authors: Hur B; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.; Microbiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States., Gupta VK; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.; Microbiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States., Oh M; School of Software Convergence, Myongji University, Seoul, Republic of Korea., Zeng H; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.; Department of Immunology, Mayo Clinic, Rochester, MN, United States., Crowson CS; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States., Warrington KJ; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States., Myasoedova E; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States., Kronzer VL; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States., Davis JM 3rd; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States., Sung J; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.; Microbiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States.; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.
Source: Frontiers in immunology [Front Immunol] 2025 Oct 29; Vol. 16, pp. 1667662. Date of Electronic Publication: 2025 Oct 29 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis.
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  Data: <searchLink fieldCode="AU" term="%22Hur+B%22">Hur B</searchLink>; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.; Microbiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Gupta+VK%22">Gupta VK</searchLink>; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.; Microbiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Oh+M%22">Oh M</searchLink>; School of Software Convergence, Myongji University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.; Department of Immunology, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Crowson+CS%22">Crowson CS</searchLink>; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Warrington+KJ%22">Warrington KJ</searchLink>; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Myasoedova+E%22">Myasoedova E</searchLink>; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Kronzer+VL%22">Kronzer VL</searchLink>; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Davis+JM+3rd%22">Davis JM 3rd</searchLink>; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.<br /><searchLink fieldCode="AU" term="%22Sung+J%22">Sung J</searchLink>; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.; Microbiomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States.; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 Oct 29; Vol. 16, pp. 1667662. <i>Date of Electronic Publication: </i>2025 Oct 29 (<i>Print Publication: </i>2025).
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              Text: 2025 Oct 29
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