The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS.
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| Title: | The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS. |
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| Authors: | Streltsov VA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia; CSIRO, Manufacturing Division, 343 Royal Parade, Parkville, Victoria 3052, Australia. Electronic address: victor.streltsov@florey.edu.au., Ganio KE; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia., Nuttall SD; CSIRO, Manufacturing Division, 343 Royal Parade, Parkville, Victoria 3052, Australia., Hernandez JA; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, United States of America., Dennys CN; Alcyone Therapeutics, 116 John Street, Suite 300, Lowell, MA, United States of America., Crouch PJ; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC 3010, Australia., Estevez AG; Center for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL 34987, USA., Franco MC; Center for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL 34987, USA., Beckman JS; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Electronic address: joe.beckman@oregonstate.edu., Roberts BR; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: blaine.roberts@emory.edu. |
| Source: | Neurobiology of disease [Neurobiol Dis] 2025 Dec; Vol. 217, pp. 107189. Date of Electronic Publication: 2025 Nov 12. |
| Publication Type: | Journal Article; Research Support, N.I.H., Intramural |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41237982 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Streltsov+VA%22">Streltsov VA</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia; CSIRO, Manufacturing Division, 343 Royal Parade, Parkville, Victoria 3052, Australia. Electronic address: victor.streltsov@florey.edu.au.<br /><searchLink fieldCode="AU" term="%22Ganio+KE%22">Ganio KE</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Nuttall+SD%22">Nuttall SD</searchLink>; CSIRO, Manufacturing Division, 343 Royal Parade, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Hernandez+JA%22">Hernandez JA</searchLink>; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, United States of America.<br /><searchLink fieldCode="AU" term="%22Dennys+CN%22">Dennys CN</searchLink>; Alcyone Therapeutics, 116 John Street, Suite 300, Lowell, MA, United States of America.<br /><searchLink fieldCode="AU" term="%22Crouch+PJ%22">Crouch PJ</searchLink>; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Estevez+AG%22">Estevez AG</searchLink>; Center for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL 34987, USA.<br /><searchLink fieldCode="AU" term="%22Franco+MC%22">Franco MC</searchLink>; Center for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL 34987, USA.<br /><searchLink fieldCode="AU" term="%22Beckman+JS%22">Beckman JS</searchLink>; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Electronic address: joe.beckman@oregonstate.edu.<br /><searchLink fieldCode="AU" term="%22Roberts+BR%22">Roberts BR</searchLink>; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: blaine.roberts@emory.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2025 Dec; Vol. 217, pp. 107189. <i>Date of Electronic Publication: </i>2025 Nov 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Intramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9500169 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-953X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209699961%22">09699961 </searchLink><i>NLM ISO Abbreviation: </i>Neurobiol Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41237982 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.nbd.2025.107189 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 107189 Titles: – TitleFull: The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Streltsov VA – PersonEntity: Name: NameFull: Ganio KE – PersonEntity: Name: NameFull: Nuttall SD – PersonEntity: Name: NameFull: Hernandez JA – PersonEntity: Name: NameFull: Dennys CN – PersonEntity: Name: NameFull: Crouch PJ – PersonEntity: Name: NameFull: Estevez AG – PersonEntity: Name: NameFull: Franco MC – PersonEntity: Name: NameFull: Beckman JS – PersonEntity: Name: NameFull: Roberts BR IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2025 Dec Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1095-953X Numbering: – Type: volume Value: 217 Titles: – TitleFull: Neurobiology of disease Type: main |
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