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GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology.

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Title: GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology.
Authors: Luben RN; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK. r.luben@ucl.ac.uk.; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. r.luben@ucl.ac.uk., Biradar MI; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Stuart KV; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Hu R; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Sun Z; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Li Z; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing, China., Do T; Vietnam National Eye Hospital, Hanoi, Vietnam.; University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam., Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong., Nakano M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Tashiro K; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ikeda Y; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Tokuda Y; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Tanaka M; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Omi N; Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan., Ueno M; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Sotozono C; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kinoshita S; Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Mori K; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kitnarong N; Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Fea A; Dipartimento di Scienze Chirurgiche, Università di Torino, Turin, Italy., Melo MB; Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Campinas, Brazil., Vasconcellos JPC; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil., Costa VP; Departamento de Oftalmologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil., Nongpiur ME; Duke-NUS Medical School, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore., Ho CL; Duke-NUS Medical School, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore., Perera SA; Duke-NUS Medical School, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore., Craig JE; Department of Ophthalmology, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Kolovos A; Department of Ophthalmology, Flinders Health and Medical Research Institute, Bedford Park, SA, Australia., Liza-Sharmini AT; Department of Ophthalmology and Visual Science and Hospital Pakar Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia., Leuenberger EU; Asian Eye Institute and University of the East Ramon Magsaysay College of Medicine, Manila, Philippines., Park KH; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea., Vijaya L; Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India., George R; Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India., Aung T; Duke-NUS Medical School, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore., Foster PJ; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Hysi P; Twin Research and Genetic Epidemiology and Ophthalmology, King's College London, London, UK.; Institute of Child Health, University College London, London, UK.; Sørlandet Sykehus Arendal, Arendal, Norway., Khawaja AP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Source: Nature communications [Nat Commun] 2025 Nov 14; Vol. 16 (1), pp. 10003. Date of Electronic Publication: 2025 Nov 14.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-64949-z