Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis.

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Title: Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis.
Authors: Naim G; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Romano-Zadaka H; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Amidror S; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Jessula Levy D; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Cohen A; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Sochen C; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Gilberg H; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Farah N; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Rudenko V; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Yarden Y; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Feng M; The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Tsentsarevsky R; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Brodie Z; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Reich Y; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Simon A; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Toister E; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Shoval I; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Armon L; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Schiller M; Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, Israel., Mandel Y; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel., Biton M; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Yissachar N; The Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. nissan.yissachar@biu.ac.il.; Bar-Ilan Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel. nissan.yissachar@biu.ac.il.
Source: Nature communications [Nat Commun] 2025 Nov 14; Vol. 16 (1), pp. 10010. Date of Electronic Publication: 2025 Nov 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-64995-7